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Peptide-based anticancer vaccines: The making and unmaking of a T-cell graveyard

Poorly biodegradable, incomplete Freund’s adjuvant (IFA)-based anticancer vaccines primed CD8(+) T cells that did not localize to the tumor site but to the persisting, antigen-rich vaccination site, which became a T-cell graveyard. Short-lived, water-based formulations and the provision of immunosti...

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Autori principali: Hailemichael, Yared, Overwijk, Willem W
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782014/
https://ncbi.nlm.nih.gov/pubmed/24073366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24743
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