Predicting Functionally Informative Mutations in Escherichia coli BamA Using Evolutionary Covariance Analysis

The essential outer membrane β-barrel protein BamA forms a complex with four lipoprotein partners BamBCDE that assembles β-barrel proteins into the outer membrane of Escherichia coli. Detailed genetic studies have shown that BamA cycles through multiple conformations during substrate assembly, sugge...

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Bibliographic Details
Main Authors: Dwyer, Robert S., Ricci, Dante P., Colwell, Lucy J., Silhavy, Thomas J., Wingreen, Ned S.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2013
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781972/
https://ncbi.nlm.nih.gov/pubmed/23934888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.155861
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