Induction of Antagonistic Soluble Decoy Receptor Tyrosine Kinases by Intronic PolyA Activation

Alternative intronic polyadenylation (IPA) can generate truncated protein isoforms with significantly altered functions. Here, we describe 31 dominant-negative, secreted variant isoforms of receptor tyrosine kinases (RTKs) that are produced by activation of intronic poly(A) sites. We show that block...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Vorlová, Sandra, Rocco, Gina, LeFave, Clare V., Jodelka, Francine M., Hess, Ken, Hastings, Michelle L., Henke, Erik, Cartegni, Luca
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2011
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781938/
https://ncbi.nlm.nih.gov/pubmed/21925381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.009
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