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Effects of Ketoconazole on the Pharmacokinetics of Ponatinib in Healthy Subjects
Ponatinib is a BCR-ABL tyrosine kinase inhibitor (TKI) approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome–positive acute lymphoblastic leukemia in patients resistant or intolerant to prior TKIs. In vitro studies suggested that metabolism of ponatinib is partially medi...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Blackwell Publishing Ltd
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3781849/ https://ncbi.nlm.nih.gov/pubmed/23801357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.109 |
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