Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes Development

Prohibitins are highly conserved proteins mainly implicated in the maintenance of mitochondrial function and architecture. Their dysfunctions are associated with aging, cancer, obesity, and inflammation. However, their possible role in pancreatic β-cells remains unknown. The current study documents...

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Главные авторы: Supale, Sachin, Thorel, Fabrizio, Merkwirth, Carsten, Gjinovci, Asllan, Herrera, Pedro L., Scorrano, Luca, Meda, Paolo, Langer, Thomas, Maechler, Pierre
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2013
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781460/
https://ncbi.nlm.nih.gov/pubmed/23863811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0152
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