Loss of Prohibitin Membrane Scaffolds Impairs Mitochondrial Architecture and Leads to Tau Hyperphosphorylation and Neurodegeneration

Fusion and fission of mitochondria maintain the functional integrity of mitochondria and protect against neurodegeneration, but how mitochondrial dysfunctions trigger neuronal loss remains ill-defined. Prohibitins form large ring complexes in the inner membrane that are composed of PHB1 and PHB2 sub...

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Detalhes bibliográficos
Main Authors: Merkwirth, Carsten, Martinelli, Paola, Korwitz, Anne, Morbin, Michela, Brönneke, Hella S., Jordan, Sabine D., Rugarli, Elena I., Langer, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3493444/
https://ncbi.nlm.nih.gov/pubmed/23144624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003021
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