Olanzapine Activates Hepatic Mammalian Target of Rapamycin: New Mechanistic Insight into Metabolic Dysregulation with Atypical Antipsychotic Drugs

Olanzapine (OLZ), an effective treatment of schizophrenia and other disorders, causes weight gain and metabolic syndrome. Most studies to date have focused on the potential effects of OLZ on the central nervous system’s mediation of weight; however, peripheral changes in liver or other key metabolic...

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Main Authors: Schmidt, Robin H., Jokinen, Jenny D., Massey, Veronica L., Falkner, K. Cameron, Shi, Xue, Yin, Xinmin, Zhang, Xiang, Beier, Juliane I., Arteel, Gavin E.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2013
Fag:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781405/
https://ncbi.nlm.nih.gov/pubmed/23926289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.207621
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