Insights into Insulin-Mediated Regulation of CYP2E1: miR-132/-212 Targeting of CYP2E1 and Role of Phosphatidylinositol 3-Kinase, Akt (Protein Kinase B), Mammalian Target of Rapamycin Signaling in Regulating miR-132/-212 and miR-122/-181a Expression in Primary Cultured Rat Hepatocytes

Several microRNAs (miRNAs) were selected for characterization of their response to insulin signaling based on in silico predictions of targeting CYP2E1 mRNA and previous reports implicating their role in hepatic metabolism and disease. CYP2E1 expression decreases with increasing insulin concentratio...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Shukla, Upasana, Tumma, Nithin, Gratsch, Theresa, Dombkowski, Alan, Novak, Raymond F.
التنسيق: Artigo
اللغة:Inglês
منشور في: The American Society for Pharmacology and Experimental Therapeutics 2013
الموضوعات:
Special Section on Epigenetic Regulation of Drug Metabolizing Enzymes and Transporters
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781375/
https://ncbi.nlm.nih.gov/pubmed/23920219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.052860
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