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Retargeting T Cells for HER2-Positive Tumor Killing by a Bispecific Fv-Fc Antibody

To exploit the biological and pharmacological properties of immunoglobulin constant domain Fc fragment and increase the killing efficacy of T cells, a single chain variable fragment specific to CD3 was fused with Fcab (Fc antigen binding), a mutant Fc fragment with specificity against Human epiderma...

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Hlavní autoři: Wang, Lei, He, Yanran, Zhang, Ge, Ma, Juan, Liu, Changzhen, He, Wen, Wang, Wei, Han, Huamin, Boruah, Bhargavi M., Gao, Bin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781095/
https://ncbi.nlm.nih.gov/pubmed/24086580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075589
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