Mutant Huntingtin Gene-Dose Impacts on Aggregate Deposition, DARPP32 Expression and Neuroinflammation in HdhQ150 Mice

Huntington's disease (HD) is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the huntingtin gene. The encoded poly-glutamine stretch renders mutant huntingtin prone to aggregation. HdhQ150 mice genocopy a pathogenic repeat (∼...

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Bibliografiska uppgifter
Huvudupphovsmän: Young, Douglas, Mayer, Franziska, Vidotto, Nella, Schweizer, Tatjana, Berth, Ramon, Abramowski, Dorothee, Shimshek, Derya R., van der Putten, P. Herman, Schmid, Peter
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781050/
https://ncbi.nlm.nih.gov/pubmed/24086450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075108
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