Mutant Huntingtin Gene-Dose Impacts on Aggregate Deposition, DARPP32 Expression and Neuroinflammation in HdhQ150 Mice

Huntington's disease (HD) is an autosomal dominant, progressive and fatal neurological disorder caused by an expansion of CAG repeats in exon-1 of the huntingtin gene. The encoded poly-glutamine stretch renders mutant huntingtin prone to aggregation. HdhQ150 mice genocopy a pathogenic repeat (∼...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Young, Douglas, Mayer, Franziska, Vidotto, Nella, Schweizer, Tatjana, Berth, Ramon, Abramowski, Dorothee, Shimshek, Derya R., van der Putten, P. Herman, Schmid, Peter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3781050/
https://ncbi.nlm.nih.gov/pubmed/24086450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075108
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