A Novel Monoclonal Antibody to Secreted Frizzled Related Protein 2 Inhibits Tumor Growth

Secreted frizzled related protein 2 (SFRP2) is overexpressed in human angiosarcoma and breast cancer, and stimulates angiogenesis via activation of the calcineurin/ NFATc3 pathway. There are conflicting reports in the literature as to whether SFRP2 is an antagonist or agonist of ß-catenin. The aims...

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Hlavní autoři: Fontenot, Emily, Rossi, Emma, Mumper, Russell, Snyder, Stephanie, Siamakpour-Reihani, Sharareh, Ma, Ping, Hilliard, Eleanor, Bone, Bradley, Ketelsen, David, Santos, Charlene, Patterson, Cam, Klauber-DeMore, Nancy
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780986/
https://ncbi.nlm.nih.gov/pubmed/23604067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1066
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