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Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition
Antifolates, folate analogs that inhibit vitamin B(9) (folic acid)-using cellular enzymes, have been used over several decades for the treatment of cancer and inflammatory diseases. Cellular uptake of the antifolates in clinical use occurs primarily via widely expressed facilitative membrane transpo...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3780903/ https://ncbi.nlm.nih.gov/pubmed/23934049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308827110 |
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