A helix-breaking mutation in the epithelial Ca(2+) channel TRPV5 leads to reduced Ca(2+)-dependent inactivation

TRPV5, a member of transient receptor potential (TRP) superfamily of ion channels, plays a crucial role in epithelial calcium transport in the kidney. This channel has a high selectivity for Ca(2+) and is tightly regulated by intracellular Ca(2+) concentrations. Recently it was shown that the molecu...

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Bibliographic Details
Main Authors: Lee, Kyu Pil, Nair, Anil V., Grimm, Christian, van Zeeland, Femke, Heller, Stefan, Bindels, René J.M., Hoenderop, Joost G.J.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780571/
https://ncbi.nlm.nih.gov/pubmed/21035851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2010.09.007
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