Mercaptoacetamide-based class II HDAC inhibitor lowers Aβ levels and improves learning and memory in a mouse model of Alzheimer's disease

Histone deacetylase inhibitors (HDACIs) alter gene expression epigenetically by interfering with the normal functions of HDAC. Given their ability to decrease Aβ levels, HDACIs area potential treatment for Alzheimer's disease (AD). However, it is unclear how HDACIs alter Aβ levels. We developed...

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Detalhes bibliográficos
Main Authors: Sung, You Me, Lee, Taehee, Yoon, Hyejin, DiBattista, Amanda Marie, Song, JungMin, Sohn, Yoojin, Moffat, Emily Isabella, Turner, R. Scott, Jung, Mira, Kim, Jungsu, Hoe, Hyang-Sook
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3780389/
https://ncbi.nlm.nih.gov/pubmed/23063601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2012.10.005
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