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The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein
Recent studies revealed that elk-like S170N/N174T mutation in mouse prion protein (moPrP), which results in an increased rigidity of β2-α2 loop, leads to a prion disease in transgenic mice. Here we characterized the effect of this mutation on biophysical properties of moPrP. Despite similar thermody...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2013
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3779884/ https://ncbi.nlm.nih.gov/pubmed/23892077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.07.023 |
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