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The effect of β2-α2 loop mutation on amyloidogenic properties of the prion protein

Recent studies revealed that elk-like S170N/N174T mutation in mouse prion protein (moPrP), which results in an increased rigidity of β2-α2 loop, leads to a prion disease in transgenic mice. Here we characterized the effect of this mutation on biophysical properties of moPrP. Despite similar thermody...

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Detalhes bibliográficos
Main Authors: Dutta, Arpana, Chen, Shugui, Surewicz, Witold K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779884/
https://ncbi.nlm.nih.gov/pubmed/23892077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.07.023
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