Cluster of Differentiation 38 (CD38) Mediates Bile Acid-induced Acinar Cell Injury and Pancreatitis through Cyclic ADP-ribose and Intracellular Calcium Release

Aberrant Ca(2+) signals within pancreatic acinar cells are an early and critical feature in acute pancreatitis, yet it is unclear how these signals are generated. An important mediator of the aberrant Ca(2+) signals due to bile acid exposure is the intracellular Ca(2+) channel ryanodine receptor. On...

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Główni autorzy: Orabi, Abrahim I., Muili, Kamaldeen A., Javed, Tanveer A., Jin, Shunqian, Jayaraman, Thottala, Lund, Frances E., Husain, Sohail Z.
Format: Artigo
Język:Inglês
Wydane: American Society for Biochemistry and Molecular Biology 2013
Hasła przedmiotowe:
Signal Transduction
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779711/
https://ncbi.nlm.nih.gov/pubmed/23940051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.494534
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