Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury

Acute pancreatitis is a major health burden for which there are currently no targeted therapies. Premature activation of digestive proenzymes, or zymogens, within the pancreatic acinar cell is an early and critical event in this disease. A high-amplitude, sustained rise in acinar cell Ca(2+) is requ...

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Bibliographic Details
Main Authors: Muili, Kamaldeen A., Ahmad, Mahwish, Orabi, Abrahim I., Mahmood, Syeda M., Shah, Ahsan U., Molkentin, Jeffery D., Husain, Sohail Z.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Pancreas
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355562/
https://ncbi.nlm.nih.gov/pubmed/22323127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00545.2011
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