Evaluation of Ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer

Preclinical reports support the concept of synergy between cancer vaccines and immune checkpoint blockade in non-immunogenic tumors. In particular, cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) antibodies have been successfully combined with GM-CSF cell-based vaccines (GVAX). Ipilimumab (anti...

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Main Authors: Le, Dung T., Lutz, Eric, Uram, Jennifer N., Sugar, Elizabeth A., Onners, Beth, Solt, Sara, Zheng, Lei, Diaz, Luis A., Donehower, Ross C., Jaffee, Elizabeth M., Laheru, Daniel A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779664/
https://ncbi.nlm.nih.gov/pubmed/23924790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e31829fb7a2
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