Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis

Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive weakness and neuropathologically by loss of motor neurons. Phenotypically, there is marked heterogeneity. Typical ALS has mixed upper motor neuron (UMN) and lower motor neuron (LMN) involvement. Primary lateral sclero...

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Detalhes bibliográficos
Main Authors: Ravits, John, Appel, Stanley, Baloh, Robert H., Barohn, Richard, Brooks, Benjamin Rix, Elman, Lauren, Floeter, Mary Kay, Henderson, Christopher, Lomen-Hoerth, Catherine, Macklis, Jeffrey D., Mccluskey, Leo, Mitsumoto, Hiroshi, Przedborski, Serge, Rothstein, Jeffrey, Trojanowski, John Q., Van Den Berg, Leonard H., Ringel, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779649/
https://ncbi.nlm.nih.gov/pubmed/23678876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21678421.2013.778548
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