Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis

Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive weakness and neuropathologically by loss of motor neurons. Phenotypically, there is marked heterogeneity. Typical ALS has mixed upper motor neuron (UMN) and lower motor neuron (LMN) involvement. Primary lateral sclero...

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Autori principali: Ravits, John, Appel, Stanley, Baloh, Robert H., Barohn, Richard, Brooks, Benjamin Rix, Elman, Lauren, Floeter, Mary Kay, Henderson, Christopher, Lomen-Hoerth, Catherine, Macklis, Jeffrey D., Mccluskey, Leo, Mitsumoto, Hiroshi, Przedborski, Serge, Rothstein, Jeffrey, Trojanowski, John Q., Van Den Berg, Leonard H., Ringel, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779649/
https://ncbi.nlm.nih.gov/pubmed/23678876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21678421.2013.778548
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