Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis

Amyotrophic lateral sclerosis (ALS) is characterized phenotypically by progressive weakness and neuropathologically by loss of motor neurons. Phenotypically, there is marked heterogeneity. Typical ALS has mixed upper motor neuron (UMN) and lower motor neuron (LMN) involvement. Primary lateral sclero...

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Autors principals: Ravits, John, Appel, Stanley, Baloh, Robert H., Barohn, Richard, Brooks, Benjamin Rix, Elman, Lauren, Floeter, Mary Kay, Henderson, Christopher, Lomen-Hoerth, Catherine, Macklis, Jeffrey D., Mccluskey, Leo, Mitsumoto, Hiroshi, Przedborski, Serge, Rothstein, Jeffrey, Trojanowski, John Q., Van Den Berg, Leonard H., Ringel, Steven
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779649/
https://ncbi.nlm.nih.gov/pubmed/23678876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/21678421.2013.778548
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