Elevated prothrombin promotes venous, but not arterial, thrombosis in mice

OBJECTIVE: Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thromb...

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Main Authors: Aleman, Maria M., Walton, Bethany L., Byrnes, James R., Wang, Jian-Guo, Heisler, Matthew J., Machlus, Kellie R., Cooley, Brian C., Wolberg, Alisa S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779620/
https://ncbi.nlm.nih.gov/pubmed/23723374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.113.301607
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