Macrophage Folate Receptor-Targeted Antiretroviral Therapy Facilitates Drug Entry, Retention, Antiretroviral Activities and Biodistribution for Reduction of Human Immunodeficiency Virus Infections

Macrophages serve as vehicles for the carriage and delivery of polymer-coated nanoformulated antiretroviral therapy (nanoART). Although superior to native drug, high drug concentrations are required for viral inhibition. Herein, folate-modified atazanavir/ritonavir (ATV/r)-encased polymers facilitat...

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Hauptverfasser: Puligujja, Pavan, McMillan, JoEllyn, Kendrick, Lindsey, Li, Tianyuzi, Balkundi, Shantanu, Smith, Nathan, Veerubhotla, Ram S., Edagwa, Benson J., Kabanov, Alexander V., Bronich, Tatiana, Gendelman, Howard E., Liu, Xin-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779529/
https://ncbi.nlm.nih.gov/pubmed/23680933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2013.05.003
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