Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca(2+) homeostasis

Miner1 is a redox-active 2Fe2S cluster protein. Mutations in Miner1 result in Wolfram Syndrome, a metabolic disease associated with diabetes, blindness, deafness, and a shortened lifespan. Embryonic fibroblasts from Miner1(−/−) mice displayed ER stress and showed hallmarks of the unfolded protein re...

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Bibliografiska uppgifter
Huvudupphovsmän: Wiley, Sandra E, Andreyev, Alexander Y, Divakaruni, Ajit S, Karisch, Robert, Perkins, Guy, Wall, Estelle A, van der Geer, Peter, Chen, Yi-Fan, Tsai, Ting-Fen, Simon, Melvin I, Neel, Benjamin G, Dixon, Jack E, Murphy, Anne N
Materialtyp: Artigo
Språk:Inglês
Publicerad: WILEY-VCH Verlag 2013
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779451/
https://ncbi.nlm.nih.gov/pubmed/23703906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201429
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