SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease

X-linked lymphoproliferative disease (XLP1) arises from mutations in the gene encoding SLAM-associated protein (SAP) and leads to abnormalities of NKT-cell development, NK-cell cytotoxicity, and T-dependent humoral function. Curative treatment is limited to allogeneic hematopoietic stem cell (HSC) t...

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Bibliographic Details
Main Authors: Rivat, Christine, Booth, Claire, Alonso-Ferrero, Maria, Blundell, Michael, Sebire, Neil J., Thrasher, Adrian J., Gaspar, H. Bobby
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Plenary Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779401/
https://ncbi.nlm.nih.gov/pubmed/23223356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-07-445858
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