Depletion of Bone Marrow-derived Macrophages Perturbs the Innate Immune Response to Surgery and Reduces Postoperative Memory Dysfunction

BACKGROUND: According to rodent models of postoperative cognitive decline, activation of the innate immune response following aseptic surgical trauma results in the elaboration of hippocampal proinflammatory cytokines, which are capable of disrupting long-term potentiation, the neurobiologic correla...

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Autores principales: Degos, Vincent, Vacas, Susana, Han, Zhenying, van Rooijen, Nico, Gressens, Pierre, Su, Hua, Young, William L., Maze, Mervyn
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779063/
https://ncbi.nlm.nih.gov/pubmed/23426204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0b013e3182834d94
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