Regional brain volume differences in symptomatic and presymptomatic carriers of familial Alzheimer’s disease mutations

BACKGROUND: Mutations in the presenilin (PSEN1, PSEN2) and amyloid precursor protein (APP) genes cause familial Alzheimer’s disease (FAD) in a nearly fully penetrant, autosomal dominant manner, providing a unique opportunity to study presymptomatic individuals who can be predicted to develop Alzheim...

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Detalhes bibliográficos
Main Authors: Lee, Grace J, Lu, Po H, Medina, Luis D, Rodriguez-Agudelo, Yaneth, Melchor, Stephanie, Coppola, Giovanni, Braskie, Meredith N, Hua, Xue, Apostolova, Liana G, Leow, Alex D, Thompson, Paul M, Ringman, John M
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779052/
https://ncbi.nlm.nih.gov/pubmed/23085935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp-2011-302087
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