Microneedle mediated intradermal delivery of adjuvanted recombinant HIV-1 CN54gp140 effectively primes mucosal boost inoculations

Dissolving polymeric microneedle arrays formulated to contain recombinant CN54 HIVgp140 and the TLR4 agonist adjuvant MPLA were assessed for their ability to elicit antigen-specific immunity. Using this novel microneedle system we successfully primed antigen-specific responses that were further boos...

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Main Authors: Pattani, Aditya, McKay, Paul F., Garland, Martin J., Curran, Rhonda M., Migalska, Katarzyna, Cassidy, Corona M., Malcolm, R. Karl, Shattock, Robin J., McCarthy, Helen O., Donnelly, Ryan F.
格式: Artigo
語言:Inglês
出版: Elsevier Science Publishers 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778941/
https://ncbi.nlm.nih.gov/pubmed/22960496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.07.039
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