Effect of Ribavirin on Viral Kinetics and Liver Gene Expression in Chronic Hepatitis C

OBJECTIVE: Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of response and mechanism of action of ribavirin in treatment of hepatitis C. DESIGN: 70 treatment-naïve patients were randomized t...

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Main Authors: Rotman, Yaron, Noureddin, Mazen, Feld, Jordan J, Guedj, Jeremie, Witthaus, Michael, Han, Hwalih, Park, Yoon J, Park, Su-Hyung, Heller, Theo, Ghany, Marc G, Doo, Edward, Koh, Christopher, Abdalla, Adil, Gara, Naveen, Sarkar, Souvik, Thomas, Emmanuel, Ahlenstiel, Golo, Edlich, Birgit, Titerence, Rachel, Hogdal, Leah, Rehermann, Barbara, Dahari, Harel, Perelson, Alan S, Hoofnagle, Jay H, Liang, T Jake
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778097/
https://ncbi.nlm.nih.gov/pubmed/23396509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-303852
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