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Blocking Apoptotic Signaling Rescues Axon Guidance in Netrin Mutants
Netrins are guidance cues that form gradients to guide growing axons. We uncover a mechanism for axon guidance by demonstrating that axons can accurately navigate in the absence of a Netrin gradient if apoptotic signaling is blocked. Deletion of the two Drosophila NetA and NetB genes leads to guidan...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3777441/ https://ncbi.nlm.nih.gov/pubmed/23499445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.02.017 |
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