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B Cell Signal Transduction in Germinal Center B Cells is Short-Circuited by Increased Phosphatase Activity

Germinal centers (GCs) generate memory B and plasma cells, essential for long-lived humoral immunity. GC B cells with high affinity B cell receptors (BCRs) are selectively expanded. To enable this selection, BCRs of such cells are thought to signal differently from those with lower affinity. We show...

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Main Authors: Khalil, Ashraf M., Cambier, John C., Shlomchik, Mark J.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777391/
https://ncbi.nlm.nih.gov/pubmed/22555432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213368
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