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B Cell Signal Transduction in Germinal Center B Cells is Short-Circuited by Increased Phosphatase Activity
Germinal centers (GCs) generate memory B and plasma cells, essential for long-lived humoral immunity. GC B cells with high affinity B cell receptors (BCRs) are selectively expanded. To enable this selection, BCRs of such cells are thought to signal differently from those with lower affinity. We show...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3777391/ https://ncbi.nlm.nih.gov/pubmed/22555432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1213368 |
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