Whole-exome sequencing and imaging genetics identify functional variants for rate of change in hippocampal volume in mild cognitive impairment

Whole-exome sequencing of individuals with mild cognitive impairment, combined with genotype imputation, was used to identify coding variants other than the apolipoprotein E (APOE) ε4 allele associated with rate of hippocampal volume loss using an extreme trait design. Matched unrelated APOE ε3 homo...

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Main Authors: Nho, K, Corneveaux, JJ, Kim, S, Lin, H, Risacher, SL, Shen, L, Swaminathan, S, Ramanan, VK, Liu, Y, Foroud, T, Inlow, MH, Siniard, AL, Reiman, RA, Aisen, PS, Petersen, RC, Green, RC, Jack, CR, Weiner, MW, Baldwin, CT, Lunetta, K, Farrer, LA, Furney, SJ, Lovestone, S, Simmons, A, Mecocci, P, Vellas, B, Tsolaki, M, Kloszewska, I, Soininen, H, McDonald, BC, Farlow, MR, Ghetti, B, Huentelman, MJ, Saykin, AJ
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777294/
https://ncbi.nlm.nih.gov/pubmed/23608917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2013.24
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