Protective Variant for Hippocampal Atrophy Identified by Whole Exome Sequencing

We used whole-exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment. An in-silico predicted missense variant in REST (rs3796529) was found exclusively in subjects with slow hippocampal volume loss and validated usi...

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Published in:Ann Neurol
Main Authors: Nho, Kwangsik, Kim, Sungeun, Risacher, Shannon L., Shen, Li, Corneveaux, Jason J., Swaminathan, Shanker, Lin, Hai, Ramanan, Vijay K., Liu, Yunlong, Foroud, Tatiana M., Inlow, Mark H., Siniard, Ashley L., Reiman, Rebecca A., Aisen, Paul S., Petersen, Ronald C., Green, Robert C., Jack, Clifford R., Weiner, Michael W., Baldwin, Clinton T., Lunetta, Kathryn L., Farrer, Lindsay A., Furney, Simon J., Lovestone, Simon, Simmons, Andrew, Mecocci, Patrizia, Vellas, Bruno, Tsolaki, Magda, Kloszewska, Iwona, Soininen, Hilkka, McDonald, Brenna C., Farlow, Martin R., Ghetti, Bernardino, Huentelman, Matthew J., Saykin, Andrew J.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387567/
https://ncbi.nlm.nih.gov/pubmed/25559091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24349
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