Protective Variant for Hippocampal Atrophy Identified by Whole Exome Sequencing

We used whole-exome sequencing to identify variants other than APOE associated with the rate of hippocampal atrophy in amnestic mild cognitive impairment. An in-silico predicted missense variant in REST (rs3796529) was found exclusively in subjects with slow hippocampal volume loss and validated usi...

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Gepubliceerd in:Ann Neurol
Hoofdauteurs: Nho, Kwangsik, Kim, Sungeun, Risacher, Shannon L., Shen, Li, Corneveaux, Jason J., Swaminathan, Shanker, Lin, Hai, Ramanan, Vijay K., Liu, Yunlong, Foroud, Tatiana M., Inlow, Mark H., Siniard, Ashley L., Reiman, Rebecca A., Aisen, Paul S., Petersen, Ronald C., Green, Robert C., Jack, Clifford R., Weiner, Michael W., Baldwin, Clinton T., Lunetta, Kathryn L., Farrer, Lindsay A., Furney, Simon J., Lovestone, Simon, Simmons, Andrew, Mecocci, Patrizia, Vellas, Bruno, Tsolaki, Magda, Kloszewska, Iwona, Soininen, Hilkka, McDonald, Brenna C., Farlow, Martin R., Ghetti, Bernardino, Huentelman, Matthew J., Saykin, Andrew J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387567/
https://ncbi.nlm.nih.gov/pubmed/25559091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24349
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