S-1 plus irinotecan and oxaliplatin for the first-line treatment of patients with metastatic colorectal cancer: a prospective phase II study and pharmacogenetic analysis

BACKGROUND: S-1 is an oral fluoropyrimidine that mimics infusional 5-fluorouracil. The aim of this phase II trial was to explore the clinical efficacy of the triplet regimen TIROX, which consists of S-1, irinotecan and oxaliplatin. METHODS: Forty-two chemo-naive patients with metastatic colorectal c...

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Detalhes bibliográficos
Main Authors: Kim, S Y, S Hong, Y, K Shim, E, Kong, S-Y, Shin, A, Baek, J Y, Jung, K H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776990/
https://ncbi.nlm.nih.gov/pubmed/23963147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.479
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