Microtubule-associated protein tau facilitates the targeted killing of proliferating cancer cells in vitro and in a xenograft mouse tumour model in vivo

BACKGROUND: Antibody drug conjugates (ADCs) and immunotoxins (ITs) are promising anticancer immunotherapeutics. Despite their encouraging performance in clinical trials, both ADCs and ITs often suffer from disadvantages such as stoichiometrically undefined chemical linkage of the cytotoxic payload (...

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Detaylı Bibliyografya
Asıl Yazarlar: Hristodorov, D, Mladenov, R, Pardo, A, Pham, A-T, Huhn, M, Fischer, R, Thepen, T, Barth, S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
Translational Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776980/
https://ncbi.nlm.nih.gov/pubmed/23942071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.457
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