Integrase-defective Lentiviral Vectors as a Delivery Platform for Targeted Modification of Adenosine Deaminase Locus

We investigated the use of integrase-defective lentiviral vectors (IDLVs) for transient delivery of zinc finger nucleases (ZFNs) and donor templates for site-specific modification of the human adenosine deaminase (hADA) gene. Initially, we constructed IDLVs carrying ZFN monomers (Single-IDLVs) and f...

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Detalhes bibliográficos
Main Authors: Joglekar, Alok V, Hollis, Roger P, Kuftinec, Gabriela, Senadheera, Shantha, Chan, Rebecca, Kohn, Donald B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776625/
https://ncbi.nlm.nih.gov/pubmed/23857176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.106
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