RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex

Inhibition of αvβ3 or expression of mutant p53 promotes invasion into fibronectin (FN)-containing extracellular matrix (ECM) by enhancing Rab-coupling protein (RCP)–dependent recycling of α5β1 integrin. RCP and α5β1 cooperatively recruit receptor tyrosine kinases, including EGFR1, to regulate their...

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Main Authors: Jacquemet, Guillaume, Green, David M., Bridgewater, Rebecca E., von Kriegsheim, Alexander, Humphries, Martin J., Norman, Jim C., Caswell, Patrick T.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776348/
https://ncbi.nlm.nih.gov/pubmed/24019536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201302041
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