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Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice

Paradoxical seizure exacerbation by anti-epileptic medication is a well-known clinical phenomenon in epilepsy, but the cellular mechanisms remain unclear. One possibility is enhanced network disinhibition by unintended suppression of inhibitory interneurons. We investigated this hypothesis in the st...

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Detalhes bibliográficos
Main Authors: Maheshwari, Atul, Nahm, Walter K., Noebels, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3776135/
https://ncbi.nlm.nih.gov/pubmed/24065886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2013.00156
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