CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed on activated natural killer (NK) cells wherein it inhibits lysis of CEACAM1-bearing tumor cell lines. The mechanism for this is unknown. Here we show that interleukin-2-induced expression of CEACAM1 on both mouse and pr...

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Main Authors: Hosomi, Shuhei, Chen, Zhangguo, Baker, Kristi, Chen, Lanfen, Huang, Yu-Hwa, Olszak, Torsten, Zeissig, Sebastian, Wang, Jing H., Mandelboim, Ofer, Beauchemin, Nicole, Lanier, Lewis L., Blumberg, Richard S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775953/
https://ncbi.nlm.nih.gov/pubmed/23696226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201242676
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