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Metabolic flux rewiring in mammalian cell cultures
Continuous cell lines (CCLs) engage in “wasteful” glucose and glutamine metabolism that leads to accumulation of inhibitory byproducts, primarily lactate and ammonium. Advances in techniques for mapping intracellular carbon fluxes and profiling global changes in enzyme expression have led to a deepe...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3775942/ https://ncbi.nlm.nih.gov/pubmed/23726154 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.copbio.2013.04.016 |
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