Randomized Trial of Zileuton for Treatment of COPD Exacerbations Requiring Hospitalization

RATIONALE: Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations. OBJECTIVE: We sought to test the safety and efficacy of adding oral zileuton (a 5-lipoxygenase inhibitor) to usual...

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Main Authors: Woodruff, Prescott G., Albert, Richard K., Bailey, William C., Casaburi, Richard, Connett, John E., Cooper, John A. D., Criner, Gerard J., Curtis, Jeffrey L., Dransfield, Mark T., Han, Meilan K., Harnden, Sarah M., Kim, Victor, Marchetti, Nathaniel, Martinez, Fernando J., McEvoy, Charlene E., Niewoehner, Dennis E., Reilly, John J., Rice, Kathryn, Scanlon, Paul D., Scharf, Steven M., Sciurba, Frank C., Washko, George R., Lazarus, Stephen C.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775706/
https://ncbi.nlm.nih.gov/pubmed/21299475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/15412555.2010.540273
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