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Targeted transduction of CD34+ hematopoietic progenitor cells in nonpurified human mobilized peripheral blood mononuclear cells

BACKGROUND: Conventional gene-therapy applications of hematopoietic stem cells (HSCs) involve purification of CD34+ progenitor cells from the mobilized peripheral blood, ex vivo transduction of the gene of interest into them, and reinfusion of the transduced CD34+ progenitor cells into patients. Eli...

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Main Authors: Liang, Min, Pariente, Nonia, Morizono, Kouki, Chen, Irvin S. Y.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3775470/
https://ncbi.nlm.nih.gov/pubmed/19152374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1290
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