Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice

The MAPK3 Tpl2 controls innate and adaptive immunity by regulating TLR, TNF-α, and GPCR signaling in a variety of cell types. Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS-induced endotoxin shock, DSS-induced colitis, and TNF-α-induced IBD. Here, we add...

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Bibliografiske detaljer
Main Authors: Kyrmizi, Irene, Ioannou, Marianna, Hatziapostolou, Maria, Tsichlis, Philip N., Boumpas, Dimitrios T., Tassiulas, Ioannis
Format: Artigo
Sprog:Inglês
Udgivet: Society for Leukocyte Biology 2013
Fag:
Receptors, Signal Transduction, & Genes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774848/
https://ncbi.nlm.nih.gov/pubmed/23898046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0113039
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