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Tpl2 kinase regulates FcγR signaling and immune thrombocytopenia in mice
The MAPK3 Tpl2 controls innate and adaptive immunity by regulating TLR, TNF-α, and GPCR signaling in a variety of cell types. Its ablation gives rise to an anti-inflammatory phenotype characterized by resistance to LPS-induced endotoxin shock, DSS-induced colitis, and TNF-α-induced IBD. Here, we add...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society for Leukocyte Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774848/ https://ncbi.nlm.nih.gov/pubmed/23898046 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.0113039 |
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