Identification of the Plant Compound Geraniin as a Novel Hsp90 Inhibitor

Besides its function in normal cellular growth, the molecular chaperone heat shock protein 90 (Hsp90) binds to a large number of client proteins required for promoting cancer cell growth and/or survival. In an effort to discover new small molecules able to inhibit the Hsp90 ATPase and chaperoning ac...

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Bibliographic Details
Main Authors: Vassallo, Antonio, Vaccaro, Maria Carmela, De Tommasi, Nunziatina, Dal Piaz, Fabrizio, Leone, Antonella
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774728/
https://ncbi.nlm.nih.gov/pubmed/24066128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074266
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