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Accelerated puberty and late-onset hypothalamic hypogonadism in female transgenic skinny mice overexpressing leptin

Excess or loss of body fat can be associated with infertility, suggesting that adequate fat mass is essential for proper reproductive function. Leptin is an adipocyte-derived hormone that is involved in the regulation of food intake and energy expenditure, and its synthesis and secretion are markedl...

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Autors principals: Yura, Shigeo, Ogawa, Yoshihiro, Sagawa, Norimasa, Masuzaki, Hiroaki, Itoh, Hiroaki, Ebihara, Ken, Aizawa-Abe, Megumi, Fujii, Shingo, Nakao, Kazuwa
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC377463/
https://ncbi.nlm.nih.gov/pubmed/10727443
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