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Role of genetic modifiers in an orthologous rat model of ARPKD
Human data and animal models of autosomal recessive polycystic kidney disease (ARPKD) suggest that genetic factors modulate the onset and severity of the disease. We report here for the first time that ARPKD susceptibility is attenuated by introgressing the mutated Pkhd1 disease allele from the poly...
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Main Authors: | , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3774585/ https://ncbi.nlm.nih.gov/pubmed/22669842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00187.2011 |
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