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Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves’ disease

We performed genetic immunization of outbred NMRI mice, using a cDNA encoding the human thyrotropin receptor (TSHr). All mice produced antibodies capable of recognizing the recombinant receptor expressed at the surface of stably transfected Chinese hamster ovary (CHO) cells, and sera from most of th...

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Autors principals: Costagliola, Sabine, Many, Marie-Christine, Denef, Jean-François, Pohlenz, Joachim, Refetoff, Samuel, Vassart, Gilbert
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC377458/
https://ncbi.nlm.nih.gov/pubmed/10727449
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