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Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries

Arachidonic acid (AA) metabolites mediate endothelium-dependent relaxation in many vascular beds. Previously, we identified the major AA 12/15-lipoxygenase (12/15-LO) metabolite of mouse arteries as 12-hydroxyeicosatetraenoic acid (12-HETE). The goal was to determine the stereospecific configuration...

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Hlavní autoři: Siangjong, Lawan, Gauthier, Kathryn M., Pfister, Sandra L., Smyth, Emer M., Campbell, William B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774504/
https://ncbi.nlm.nih.gov/pubmed/23203967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00690.2012
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