A Novel Family of Soluble Minimal Scaffolds Provides Structural Insight into the Catalytic Domains of Integral Membrane Metallopeptidases

In the search for structural models of integral-membrane metallopeptidases (MPs), we discovered three related proteins from thermophilic prokaryotes, which we grouped into a novel family called “minigluzincins.” We determined the crystal structures of the zymogens of two of these (Pyrococcus abyssi...

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Autori principali: López-Pelegrín, Mar, Cerdà-Costa, Núria, Martínez-Jiménez, Francisco, Cintas-Pedrola, Anna, Canals, Albert, Peinado, Juan R., Marti-Renom, Marc A., López-Otín, Carlos, Arolas, Joan L., Gomis-Rüth, F. Xavier
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Enzymology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774397/
https://ncbi.nlm.nih.gov/pubmed/23733187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.476580
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